Length and Sequence Heterozygosity Differentially Affect HRAS1 Minisatellite Stability During Meiosis in Yeast
نویسندگان
چکیده
منابع مشابه
Length and sequence heterozygosity differentially affect HRAS1 minisatellite stability during meiosis in yeast.
Minisatellites, one of the major classes of repetitive DNA sequences in eukaryotic genomes, are stable in somatic cells but destabilize during meiosis. We previously established a yeast model system by inserting the human Ha-ras/HRAS1 minisatellite into the HIS4 promoter and demonstrated that our system recapitulates all of the phenotypes associated with the human minisatellite. Here we demonst...
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ژورنال
عنوان ژورنال: Genetics
سال: 2005
ISSN: 1943-2631
DOI: 10.1534/genetics.104.026278